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Vol. 31 No. 2 (2019): Vol. 31 No. 2

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Synthesis, Spectral, Antibacterial, Antifungal and Antipyretic Activities of Co(II) and Ni(II) Complexes with Bioactive Benzimidazole and Benzoate Ion

https://doi.org/10.14233/ajchem.2019.21710
T. Gomadurai
P.G. & Research Department of Chemistry, Government Arts College, Ariyalur-621713, India
K. Rajasekar
P.G. & Research Department of Chemistry, Government Arts College, Ariyalur-621713, India
S. Balasubramaniyan
P.G. & Research Department of Chemistry, Government Arts College, Ariyalur-621713, India
R. Selvarani
P.G. & Research Department of Chemistry, Government Arts College, Ariyalur-621713, India
C. Veeravel
P.G. & Research Department of Chemistry, Government Arts College, Ariyalur-621713, India
R. Geetha
P.G. & Research Department of Chemistry, Government Arts College, Ariyalur-621713, India

Corresponding Author(s) : T. Gomadurai

gomadurait@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 2 (2019): Vol. 31 No. 2

Abstract

The Co(II) and Ni(II) transition metal complexes with benzimidazole and benzoate ion was synthesized using microwave heating. The synthesized complexes were characterized by elemental analysis, metal estimation, molar conductance, cyclic voltammetry, magnetic moment and electronic spectra, IR, Far- IR spectral data. The structure and metal ligand stoichiometry of the synthesized complexes were confirmed by using elemental analysis and metal estimation. Molar conductance of 10-3 M complex solution confirming their non-electrolyte nature. The Redox behaviour of metal ions in the synthesized complexes was confirmed by cyclic voltammogram. Six coordinated geometry of complexes were concluded from magnetic moment and electronic spectra. The in vitro antibacterial activities of the ligand and its Co(II) and Ni(II) complexes were screened against Gram +ve bacteria, Bacillus, Gramve bacteria, Pseudomonas, Klebsiella pneumonia and Proteus and in vitro antifungal activities were screened against pathogenic yeast, C. albicans by agar well diffusion method. The antipyretic activities of ligand and its Ni(II) complex were evaluated by yeast- induced fever test. The percentage reduction of the sample at yeast induced temperature was deduced.

Keywords

Benzimidazole Benzoate Cobalt(II) complex Nickel(II) complex Biological activities
Gomadurai, T., Rajasekar, K., Balasubramaniyan, S., Selvarani, R., Veeravel, C., & Geetha, R. (2018). Synthesis, Spectral, Antibacterial, Antifungal and Antipyretic Activities of Co(II) and Ni(II) Complexes with Bioactive Benzimidazole and Benzoate Ion. Asian Journal of Chemistry, 31(2), 477–480. https://doi.org/10.14233/ajchem.2019.21710
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