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Vol. 31 No. 2 (2019): Vol. 31 No. 2

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Oxidative Degradation of Paliperidone Using Potassium Permangnate in Acid Medium

https://doi.org/10.14233/ajchem.2019.21604
S.S. Kurdur
Department of Chemistry, KLS Gogte Institute of Technology (Affiliated to Visvesvaraya Technological University), Belagavi-590008, India
K.A. Thabaj
Department of Chemistry, KLS Gogte Institute of Technology (Affiliated to Visvesvaraya Technological University), Belagavi-590008, India
R.M. Kulkarni
Department of Chemistry, KLS Gogte Institute of Technology (Affiliated to Visvesvaraya Technological University), Belagavi-590008, India
A.D. Kulkarni
Department of Applied Sciences, MIT Academy of Engineering (Affiliated to Savitribai Phule Pune University), Dehu Phata, Alandi (D), Pune-412105, India
D.P. Rendedula
Department of Analytical Chemistry, GVK Biosciences Pvt. Ltd., Hyderabad-500076, India
S.A. Malladi
Department of Chemistry, KLS Gogte Institute of Technology (Affiliated to Visvesvaraya Technological University), Belagavi-590008, India
P.B. Belavi
Department of Physics, KLS Gogte Institute of Technology (Affiliated to Visvesvaraya Technological University), Belagavi-590008, India

Corresponding Author(s) : K.A. Thabaj

atkiran@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 2 (2019): Vol. 31 No. 2

Abstract

Oxidative degradation reactions of paliperidone are studied using potassium permanganate in acidic medium spectrophotometrically. Complete reaction was carried out in pseudo first order condition. The reaction orders were calculated with respect to the paliperidone and acid, the obtained values indicate that these reactant have less than first order dependency on the reaction rate. Oxidation products were identified using LC-MS technique and their m/z values were found to be 207, 221 and 443. Kinetics and the mechanism of the reactions were derived from the results identified. The reactions were studied at four different temperatures with different paliperidone and acid concentrations. The activation and thermodynamic parameters were calculated by graphical method.

Keywords

Kinetics Paliperidone Oxidative degradation Mechanistic study
Kurdur, S., Thabaj, K., Kulkarni, R., Kulkarni, A., Rendedula, D., Malladi, S., & Belavi, P. (2018). Oxidative Degradation of Paliperidone Using Potassium Permangnate in Acid Medium. Asian Journal of Chemistry, 31(2), 389–392. https://doi.org/10.14233/ajchem.2019.21604
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