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Vol. 31 No. 2 (2019): Vol. 31 No. 2

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A Green Synthesis, Molecular Docking and Cytotoxicity of (E)-1-(4-(Difluoromethoxy)-2-Hydroxybenzylidene) Semicarbazide

https://doi.org/10.14233/ajchem.2019.21654
Chinnadurai Anbuselvan
Department of Chemistry, Annamalai University, Annamalainagar-608002, India

Corresponding Author(s) : Chinnadurai Anbuselvan

cas_amu@yahoo.co.in

Asian Journal of Chemistry, Vol. 31 No. 2 (2019): Vol. 31 No. 2

Abstract

A green, one-pot three-components reaction of (E)-1-(4-(difluoromethoxy)-2-hydroxybenzylidene) semicarbazide has been designed, synthesized and characterized by elemental, FT-IR, 1H and 13C NMR spectral data. The cytotoxic activities of the synthesized compound were evaluated by MTT assay in human cancer cell lines. Docking studies of 3-substituted indolin-2-one scaffolds on vascular endothelial growth factor receptor 2 (VEGFR-2) involved in cell proliferation and angiogenesis was performed. Based on the ligand efficiency indices, Schiff bases may be regarded as efficient candidates for further molecular developments of anticancer agents. The molecule is useful in sensing and drug-carrying applications.

Keywords

Green synthesis Schiff base Docking studies Cytotoxicity
Anbuselvan, C. (2018). A Green Synthesis, Molecular Docking and Cytotoxicity of (E)-1-(4-(Difluoromethoxy)-2-Hydroxybenzylidene) Semicarbazide. Asian Journal of Chemistry, 31(2), 373–377. https://doi.org/10.14233/ajchem.2019.21654
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