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Vol. 31 No. 12 (2019): Vol 31 Issue 12

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Formation Constants of Mixed Ligand Complexes of Anti-Inflammatory Drug Piroxicam and Some Bioligands with Copper(II)

https://doi.org/10.14233/ajchem.2019.22298
Amal M. Al-Mohaimeed
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
https://orcid.org/0000-0002-4883-4878

Corresponding Author(s) : Amal M. Al-Mohaimeed

muhemeed@ksu.edu.sa

Asian Journal of Chemistry, Vol. 31 No. 12 (2019): Vol 31 Issue 12

Abstract

The formation constants of various complexes of copper(II) with anti-inflammatory drug piroxicam (P) as primary ligand and some bioligands such as L-serine, L-tyrosine, L-threonine as secondary ligand have been determined pH metrically at 25 ºC and I = 0.1 M NaNO3. The results suggest that the formation of Cu(P)L and Cu(P)(LH-1) species in the pH range of 5-12. The values of Δ log10 K, percentage of relative stabilization and log X were evaluated and discussed.

Keywords

Potentiometric titration Mixed ligand complexes Amino acids Piroxicam
Al-Mohaimeed, A. M. (2019). Formation Constants of Mixed Ligand Complexes of Anti-Inflammatory Drug Piroxicam and Some Bioligands with Copper(II). Asian Journal of Chemistry, 31(12), 2937–2940. https://doi.org/10.14233/ajchem.2019.22298
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