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Synthesis and Antibacterial Evaluation of Tetrahydropyrimidine-5-carboxamide
Corresponding Author(s) : N. Edayadulla
Asian Journal of Chemistry,
Vol. 30 No. 2 (2018): Vol 30 Issue 2
Abstract
A series of new dihydropyrimidine-2H-ones/thiones were synthesized and evaluated in vitro for their antibacterial activity. Characterization of newly synthesized dihydropyrimidones was done by physical and spectral data. All the synthesized compounds were evaluated for their antibacterial activity. Amongst all, compounds 3e and 4e registered high activity against the bacterial strain when compared to standard drug.
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- C.O. Kappe, Eur. J. Med. Chem., 35, 1043 (2000); https://doi.org/10.1016/S0223-5234(00)01189-2.
- L. Ismaili,A. Nadaradjane, L. Nicod, C. Guyon, A. Xicluna, J.F. Robert and B. Refouvelet, Eur. J. Med. Chem., 43, 1270 (2008); https://doi.org/10.1016/j.ejmech.2007.07.012.
- C.O. Kappe, Acc. Chem. Res., 33, 879 (2000); https://doi.org/10.1021/ar000048h.
- K.S. Atwal, B.N. Swanson, S.E. Unger, D.M. Floyd, S. Moreland, A. Hedberg and B.C. O’Reilly, J. Med. Chem., 34, 806 (1991); https://doi.org/10.1021/jm00106a048.
- G.C. Rovnyak, K.S. Atwal, A. Hedberg, S.D. Kimball, S. Moreland, J.Z. Gougoutas, B.C. O’Reilly, J. Schwartz and M.F. Malley, J. Med. Chem., 35, 3254 (1992); https://doi.org/10.1021/jm00095a023.
- K. Rana, A. Arora, S. Bansal and R. Chawla, Indian J. Pharm. Sci., 76, 339 (2014). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171871/
- C.O. Kappe, O.V. Shishkin, G. Uray and P. Verdino, Tetrahedron, 56, 1859 (2000); https://doi.org/10.1016/S0040-4020(00)00116-2.
- R. Chikhale, S. Thorat,A. Pant,A. Jadhav, K.C. Thatipamula, R. Bansode, G. Bhargavi, N. Karodia, M.V. Rajasekharan, A. Paradkar and P. Khedekar, Bioorg. Med. Chem., 23, 6689 (2015); https://doi.org/10.1016/j.bmc.2015.09.009.
- M. Amini, L. Navidpour and A. Shafiee, Daru J. Pharm. Sci., 16, 9 (2008).
- V.N. Pathak, R. Gupta and B. Varshney, Indian J. Chem., 47B, 434 (2008). http://nopr.niscair.res.in/handle/123456789/1424.
- A.L. Barry, The Antimicrobioal Susceptibility Test: Principle & Practice, Illus Lea, Febiger & Philadelphia, p. 180 (1976).
- C.H. Collins and P.M. Lyne, Microbial Methods, University Park Press, Baltimore (1970).
- K.R. Cruickshan, J.P. Duguid, B.P. Marmion and R.H.A. Swain, Medical Microbiology. Churchill Livingstone, London, p. 260 (1989).
- C.Y. Hong, Y.K. Kim, J.H. Chang, S.H. Kim, H. Choi, D.H. Nam, Y.Z. Kim and J.H. Kwak, Med. Chem. (N.Y.), 40, 3584 (1997); https://doi.org/10.1021/jm970202e.
References
C.O. Kappe, Eur. J. Med. Chem., 35, 1043 (2000); https://doi.org/10.1016/S0223-5234(00)01189-2.
L. Ismaili,A. Nadaradjane, L. Nicod, C. Guyon, A. Xicluna, J.F. Robert and B. Refouvelet, Eur. J. Med. Chem., 43, 1270 (2008); https://doi.org/10.1016/j.ejmech.2007.07.012.
C.O. Kappe, Acc. Chem. Res., 33, 879 (2000); https://doi.org/10.1021/ar000048h.
K.S. Atwal, B.N. Swanson, S.E. Unger, D.M. Floyd, S. Moreland, A. Hedberg and B.C. O’Reilly, J. Med. Chem., 34, 806 (1991); https://doi.org/10.1021/jm00106a048.
G.C. Rovnyak, K.S. Atwal, A. Hedberg, S.D. Kimball, S. Moreland, J.Z. Gougoutas, B.C. O’Reilly, J. Schwartz and M.F. Malley, J. Med. Chem., 35, 3254 (1992); https://doi.org/10.1021/jm00095a023.
K. Rana, A. Arora, S. Bansal and R. Chawla, Indian J. Pharm. Sci., 76, 339 (2014). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171871/
C.O. Kappe, O.V. Shishkin, G. Uray and P. Verdino, Tetrahedron, 56, 1859 (2000); https://doi.org/10.1016/S0040-4020(00)00116-2.
R. Chikhale, S. Thorat,A. Pant,A. Jadhav, K.C. Thatipamula, R. Bansode, G. Bhargavi, N. Karodia, M.V. Rajasekharan, A. Paradkar and P. Khedekar, Bioorg. Med. Chem., 23, 6689 (2015); https://doi.org/10.1016/j.bmc.2015.09.009.
M. Amini, L. Navidpour and A. Shafiee, Daru J. Pharm. Sci., 16, 9 (2008).
V.N. Pathak, R. Gupta and B. Varshney, Indian J. Chem., 47B, 434 (2008). http://nopr.niscair.res.in/handle/123456789/1424.
A.L. Barry, The Antimicrobioal Susceptibility Test: Principle & Practice, Illus Lea, Febiger & Philadelphia, p. 180 (1976).
C.H. Collins and P.M. Lyne, Microbial Methods, University Park Press, Baltimore (1970).
K.R. Cruickshan, J.P. Duguid, B.P. Marmion and R.H.A. Swain, Medical Microbiology. Churchill Livingstone, London, p. 260 (1989).
C.Y. Hong, Y.K. Kim, J.H. Chang, S.H. Kim, H. Choi, D.H. Nam, Y.Z. Kim and J.H. Kwak, Med. Chem. (N.Y.), 40, 3584 (1997); https://doi.org/10.1021/jm970202e.