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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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Antibacterial Screening of New Synthesis Schiff Base having Benzimidazole Moiety

https://doi.org/10.14233/ajchem.2018.21008
Muayed Ahmed Redayan
Department of Chemistry, College of Education for Pure Sciences, Diyala University, Diyala, Iraq
Maha Salih Hussein
Department of Chemistry, College of Education, Samarra University, Salahaldin, Iraq
Ashraf Tark Lafta
Department of Chemistry, College of Education, Samarra University, Salahaldin, Iraq

Corresponding Author(s) : Muayed Ahmed Redayan

mredayan@gmail.com; muayed1976@yahoo.com

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

A new series of benzimidazole containing Schiff base moiety has been synthesized. The reaction was achieved through cyclocondensation reaction of the substituted 1,2-phenylenediamines and amino acids (glycine, alanine and tyrosine) to gave substituted benzimidazole derivatives 1(a-f). Condensation of these compounds with a variety of aromatic aldehyde yielded the new benzimidazole substituted Schiff base. The chemical structures of the synthesized compounds were confirmed by FT-IR, 1H NMR and 13C NMR. Selected compounds were tested in vitro for their antibacterial activity by disc diffusion method against two types of Gram-positive bacteria namely (Staphylococcous aureus, Bacillus subtilis) and Gram-negative bacteria namely (Pseudomonas aeruginosa, Escherichia coli). The results displayed that most of the prepared compounds have a good antibacterial activity in compared with the standard antibiotic ampicillin and ciprofloxacin.

Keywords

Benzimidazole Schiff bases Antibacterial activity 1,2-Phenylenediamine
Redayan, M. A., Hussein, M. S., & Lafta, A. T. . (2017). Antibacterial Screening of New Synthesis Schiff Base having Benzimidazole Moiety. Asian Journal of Chemistry, 30(2), 381–385. https://doi.org/10.14233/ajchem.2018.21008
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