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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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Diphosphorus Tetraiodide (P2I4): An Efficient Catalyst for Synthesis of 2-Aryl-1,3-benzazoles via Cyclocondensation of o-Amino/Mercaptan/Hydroxy Anilines with Aryl Acids

https://doi.org/10.14233/ajchem.2018.21001
Saket B. Bhagat
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400 019, India
Yogesh B. Sutar
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400 019, India
Yogesh Manohar
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400 019, India
Vikas N. Telvekar
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400 019, India

Corresponding Author(s) : Vikas N. Telvekar

vikastelvekar@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

An efficient and versatile approach for the synthesis of 2-substituted 1,3-benzazoles has been developed via diphosphorus tetraiodide (P2I4) catalyzed condensation reaction of ortho-substituted anilines (–NH2, –SH and –OH) with various aromatic acids to give benzimidazoles, benzothiazoles and benzoxazoles in excellent yields. Additionally, the synthetic approach reported herein has advantages such as mild reaction conditions, broad substrate scopes as well as simple one-pot operation, common for all the three 1,3-benzazoles, which makes this strategy highly attractive.

Keywords

Aryl/heteroaryl acids Heterocycles Benzimidazole Benzothiazole Benzoxazole Diphosphorus tetraiodide
Bhagat, S. B., Sutar, Y. B., Manohar, Y., & Telvekar, V. N. (2017). Diphosphorus Tetraiodide (P2I4): An Efficient Catalyst for Synthesis of 2-Aryl-1,3-benzazoles via Cyclocondensation of o-Amino/Mercaptan/Hydroxy Anilines with Aryl Acids. Asian Journal of Chemistry, 30(2), 376–380. https://doi.org/10.14233/ajchem.2018.21001
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