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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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Development of Solid Lipid Nanoparticles of Gac (Momordica cocochinensis Spreng) Oil by Nano-Emulsion Technique

https://doi.org/10.14233/ajchem.2018.20902
H.C. Mai
Department of Chemical Engineering and Processing, Nong Lam University, Ho Chi Minh City, Vietnam
T.T.T. Le
Department of Chemical Engineering and Processing, Nong Lam University, Ho Chi Minh City, Vietnam
T.T. Diep
Department of Chemical Engineering and Processing, Nong Lam University, Ho Chi Minh City, Vietnam
T.H.N. Le
Ho Chi Minh City University of Technology, VNU-HCM, Ho Chi Minh City, Vietnam
D.T. Nguyen
NTT of Institute of Hi-Technology, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam
L.G. Bach
NTT of Institute of Hi-Technology, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

Corresponding Author(s) : H.C. Mai

maihuynhcang@hcmuaf.edu.vn

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

Solid lipid nanoparticles have emerged as a next-generation drug delivery system with potential applications in the pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. In the present work, gac oil-loaded solid lipid nanoparticles were successfully prepared by a nano emulsion technique employing high-speed homogenizer. In this study, solid lipid nanoparticle were successfully prepared by using Emulgade SE-PFTM lipid, high-speed homogenization with the support of surfactant. The suspensions contained 5 % active agents (gac oil w/w) were dispersed in the presence of surfactant (Tween-80:Span-80 ratio of 72:28 w/w) at the content of 5 % by using the IKA homogenizer at the speed of 10000 rpm for 60 min (30 min hot homogenization and 30 min cold homogenization). The obtained mixture had the median size of 200 nm (by laser diffractometric spectrometry, LSD). Entrapment efficiency was about 90.8 %.

Keywords

Solid lipid nanoparticles Gac oil (Momordica cochinchinensis Spreng.) Homogenization Emulgade SE-PFTM
Mai, H., Le, T., Diep, T., Le, T., Nguyen, D., & Bach, L. (2017). Development of Solid Lipid Nanoparticles of Gac (Momordica cocochinensis Spreng) Oil by Nano-Emulsion Technique. Asian Journal of Chemistry, 30(2), 293–297. https://doi.org/10.14233/ajchem.2018.20902
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References
  1. G. Schnurr, N. Misawa and G. Sandmann, Biochem. J., 315, 869 (1996); https://doi.org/10.1042/bj3150869.
  2. J. Shi, Crit. Rev. Biotechnol., 20, 293 (2000); https://doi.org/10.1080/07388550091144212.
  3. N.I. Krinsky, Exp. Biol. Med., 218, 95 (1998); https://doi.org/10.3181/00379727-218-44273.
  4. L. Cao-Hoang, H. Phan-Thi, F.J. Osorio-Puentes and Y. Waché, Food Res. Int., 44, 2252 (2011); https://doi.org/10.1016/j.foodres.2011.03.036.
  5. E.S. Curtis, R. Kalafsky and E.R. Kaplan, Method of Treating the Skin with Organic Acids in Anhydrous Microsphere Delivery Systems, US Patent 5962018 A (1999).
  6. M.E. Darvin, W. Sterry, J. Lademann and T. Vergou, Molecules, 16, 10491 (2011); https://doi.org/10.3390/molecules161210491.
  7. M.D. Triplett, Ph.D. Thesis, Department of Chemical Engineering, The Ohio State University, USA, (2004).
  8. A. Garud, D. Singh and N. Garud, Int. Curr. Pharm. J., 1, 384 (2012); https://doi.org/10.3329/icpj.v1i11.12065.
  9. C. Vitorino, F.A. Carvalho, A.J. Almeida, J.J. Sousa and A.A.C.C. Pais, Colloids Surf. B Biointerfaces, 84, 117 (2011); https://doi.org/10.1016/j.colsurfb.2010.12.024.
  10. L. Genç, G. Dikmen and G. Güney, J. Mater. Sci. Eng., 5, 468 (2011).
  11. B. Lasa-Saracibar, A. Estella-Hermoso de Mendoza, M. Guada, C. DiosVieitez and M.J. Blanco-Prieto, Expert Opin. Drug Deliv., 9, 1245 (2012); https://doi.org/10.1517/17425247.2012.717928.
  12. D. Hou, C. Xie, K. Huang and C. Zhu, Biomaterials, 24, 1781 (2003); https://doi.org/10.1016/S0142-9612(02)00578-1.
  13. T.H. Le, J. Sci. Technol., 53, 159 (2015).
  14. T.H.N. Le and N.Q.A. Phan, J. Sci. Technol., 53, 159 (2015).
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