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Vol. 31 No. 6 (2019): Vol 31 Issue 6

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Modification of Clinoptilolite with Benzalkonium Chloride as a Carrier of Metformin Hydrochloride

https://doi.org/10.14233/ajchem.2019.21887
I.M.W.A. Putra
Department of Nutrition Science, Faculty of Health, Science and Technology, University of Dhyana Pura, Dalung, Badung-80361, Indonesia
https://orcid.org/0000-0001-9343-2125
I.G.A.W. Kusumawati
Department of Nutrition Science, Faculty of Health, Science and Technology, University of Dhyana Pura, Dalung, Badung-80361, Indonesia
https://orcid.org/0000-0003-0610-6378
A.W. Permadi
Department of Physioteraphy, Faculty of Health, Science and Technology, University of Dhyana Pura, Dalung, Badung-80361, Indonesia

Corresponding Author(s) : I.M.W.A. Putra

made_wisnu84@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 6 (2019): Vol 31 Issue 6

Abstract

Clinoptilolites have a limitation in the adsorption of drug molecules due to their fixed pore structure. In this study, we modified the clinoptilolite with benzalkonium chloride. The modification was carried out by stirring 1 g of NaCl activated clinoptilolite with 100 mL of benzalkonium chloride solution with a concentration of 0.5, 1, 5, 10 and 15 % at room temperature for 24 h. After filtration and drying process, benzalkonium chloride modified clinoptilolite was stirred with 100 mL of 300 mg/L metformin hydrochloride solution at room temperature for 24 h. The result of sample characterization using FTIR spectrometer, X-ray diffractometer and N2 Sorption analyzer showed that clinoptilolite modification with benzalkonium chloride and the impregnation of metformin hydrochloride proceeded well. The optimal amount of metformin hydrochloride occurred in benzalkonium chloride 1 % modified clinoptilolite.

Keywords

Clinoptilolite Benzalkonium chloride Metformin hydrochloride Surface modification
Putra, I., Kusumawati, I., & Permadi, A. (2019). Modification of Clinoptilolite with Benzalkonium Chloride as a Carrier of Metformin Hydrochloride. Asian Journal of Chemistry, 31(6), 1275–1278. https://doi.org/10.14233/ajchem.2019.21887
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