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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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Synthesis, Characterization and in vitro Cytotoxicity Studies of Pentadentate Ligand and its Copper(II) Complexes

https://doi.org/10.14233/ajchem.2018.21049
Umapathy Chokkanathan
PG & Research Department of Chemistry, Muthurangam Government Arts College, Vellore-632 002, India
Kannappan Geetha
PG & Research Department of Chemistry, Muthurangam Government Arts College, Vellore-632 002, India

Corresponding Author(s) : Kannappan Geetha

senthil_geetha@rediffmail.com

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

A pentadentate ligand was synthesized by reaction of 4-t-butyl-2,6-bis(chloromethyl)phenol and isonicotinic hydrazide. The ligand was characterized by UV-visible, FT-IR, 1H NMR, 13C NMR and mass spectrascopic techniques. The above ligand was coordinated with various copper precursors to form corresponding copper(II) complexes. The complexes were characterized by UV-visible, FT-IR, molar conductivity and cyclic voltammetry. The in vitro cytotoxicity of the ligand and its copper complexes were studied against Ehrlich ascites carcinoma (EAC) cells.

Keywords

Isonicotinic hydrazide Pentadentate ligand Copper(II) complexes in vitro cytotoxicity Ehrlich ascites carcinoma cells
Chokkanathan, U., & Geetha, K. (2017). Synthesis, Characterization and in vitro Cytotoxicity Studies of Pentadentate Ligand and its Copper(II) Complexes. Asian Journal of Chemistry, 30(2), 411–415. https://doi.org/10.14233/ajchem.2018.21049
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