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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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One Pot Multicomponent Synthesis of Anti-inflammatory Active Tetrahydrofuro[3,2-c]pyridinone-2-carboxylate Derivatives

https://doi.org/10.14233/ajchem.2018.21039
Venkata Swamy Tangeti
Department of Chemistry, Raghu Engineering College, Visakhapatnam-531 162, India; Vector Control Research Centre (Indian Council for Medical Research), Puducherry-605 006, India
Boyi Harika Reddy
Department of Chemistry, Raghu Engineering College, Visakhapatnam-531 162, India
K. Sharon Evangeline
Vector Control Research Centre (Indian Council for Medical Research), Puducherry-605 006, India

Corresponding Author(s) : Venkata Swamy Tangeti

swamychempcu8@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

A novel, one-pot method has been developed for the synthesis of tetrahydrofuro[3,2-c]pyridine-2-carboxylate derivatives via cascade four-component condensation of 6-methyl, 4-hydroxy pyranone, aryl amines, aromatic aldehydes and pyridinium ylide, in presence of triethylamine as a catalyst under ethanol reflux conditions. It affords the corresponding product in high yield (78-92 %) with short reaction time (15-25 min).The anti-inflammatory activity of these compounds was determined. Out of the 17 synthesized compounds, compounds 5j, 5k, 5l, 5m and 5n were excellent inhibitors of TNF-a and IL-6, COX-2, b-glucuronidase.

Keywords

6-Methyl 4-hydroxy pyranone Pyridinium ylied Multicomponent Furopyridinone
Tangeti, V. S., Reddy, B. H., & Evangeline, K. S. (2017). One Pot Multicomponent Synthesis of Anti-inflammatory Active Tetrahydrofuro[3,2-c]pyridinone-2-carboxylate Derivatives. Asian Journal of Chemistry, 30(2), 403–410. https://doi.org/10.14233/ajchem.2018.21039
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