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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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Synthesis, Characterization and Antiinflammatory Activity of Chalcone Derivatives Linked with Apocynin and 5-Nitrofuran Moiety

https://doi.org/10.14233/ajchem.2018.20950
A.L.V. Kumar Reddy
Department of Chemistry, Gondwana University, Gadchiroli-442 605, India
Niren E. Kathale
Department of Chemistry, Sardar Patel Mahavidyalaya, Chandrapur-442 402, India

Corresponding Author(s) : A.L.V. Kumar Reddy

alvkumar2016@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

The present paper describes the synthesis of some new chalcone derivatives i.e. 1-[3-methoxy-4-(5-nitro-furan-2-ylmethoxy)-phenyl]-3-(substituted phenyl)-propenone derivatives (9A-9K) from furfural and apocynin as starting materials. Claisen-Schmidt reaction of 1-(4-((5-nitrofuran-2-yl)methoxy)-3-methoxyphenyl)ethanone (7) with aromatic aldehydes (8A-K) under solvent free conditions using solid NaOH as catalyst at room temperature resulted in the formation of chalcone derivatives (9A-9K) in 86-96 % yield. These compounds were characterized by 1H NMR, Mass and IR spectroscopy and were evaluated for their anti-inflammatory activity.

Keywords

Anti-inflammatory activity Apocynin Chalcones Furfural Synthesis
Reddy, A. K., & Kathale, N. E. (2017). Synthesis, Characterization and Antiinflammatory Activity of Chalcone Derivatives Linked with Apocynin and 5-Nitrofuran Moiety. Asian Journal of Chemistry, 30(2), 312–316. https://doi.org/10.14233/ajchem.2018.20950
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