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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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Synthesis and Antimicrobial Properties of New Derivatives of Morpholine and Piperidine Based on 1-Chloro-3-methoxy-propylbenzene

https://doi.org/10.14233/ajchem.2018.20876
G.Sh. Duruskari
Department of Organic Chemistry, Baku State University, Z. Khalilov Str. 23, Baku, Azerbaijan
M.N. Maharramov
Department of Organic Chemistry, Baku State University, Z. Khalilov Str. 23, Baku, Azerbaijan
U.Sh. Hasanova
Department of Organic Chemistry, Baku State University, Z. Khalilov Str. 23, Baku, Azerbaijan
Kh.G. Ganbarov
Department of Microbiology, Baku State University, Z. Khalilov Str. 23, Baku, Azerbaijan
G.M. Eyvazova
Department of Organic Chemistry, Baku State University, Z. Khalilov Str. 23, Baku, Azerbaijan
A.A. Israyilova
Department of Microbiology, Baku State University, Z. Khalilov Str. 23, Baku, Azerbaijan
A.M. Maharramov
Department of Organic Chemistry, Baku State University, Z. Khalilov Str. 23, Baku, Azerbaijan

Corresponding Author(s) : G.Sh. Duruskari

gduruskari@mail.ru

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

The compounds 1-(3-methoxy-1-phenyl-propyl)morpholine and 1-(3-methoxy-1-phenyl-propyl) piperidine have been synthesized using (3-methoxy-propenyl)benzene and 1-chloro-3-methoxy-propylbenzene. The structures of the synthesized compounds were analyzed by NMR and IR spectroscopic methods. Biological activities of obtained products were investigated against Gram-negative and Gram-positive microorganisms. It has been showed that all the synthesized compounds possess pronounced antimicrobial activity against pathogenic bacteria Acinetobacter baumannii BDU32, Escherichia coli BDU12, Klebsiella pneumoniae BDU44, Pseudomonas aeruginosa BDU49 and Staphylococcus aureus BDU23.

Keywords

Ethylbenzene Ether Morpholine Piperidine Antibacterial activity Pathogenic bacteria
Duruskari, G., Maharramov, M., Hasanova, U., Ganbarov, K., Eyvazova, G., Israyilova, A., & Maharramov, A. (2017). Synthesis and Antimicrobial Properties of New Derivatives of Morpholine and Piperidine Based on 1-Chloro-3-methoxy-propylbenzene. Asian Journal of Chemistry, 30(2), 269–272. https://doi.org/10.14233/ajchem.2018.20876
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