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Vol. 30 No. 2 (2018): Vol 30 Issue 2

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Synthesis, Spectral, Thermal and Biological Studies of Some Metal Complexes Derived from Heterocyclic Mono Azo Dye Ligand 2'[(2'-Hydroxy-4-methyl phenyl)azo]imidazole

https://doi.org/10.14233/ajchem.2018.20889
Khalid J. Al-Adilee
Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniya 1753, Iraq
Saad A. Atyha
Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniya 1753, Iraq

Corresponding Author(s) : Khalid J. Al-Adilee

khalid.jawad@qu.edu.iq; khalidke_1962@yahoo.com

Asian Journal of Chemistry, Vol. 30 No. 2 (2018): Vol 30 Issue 2

Abstract

A new hetrocyclic mono azo dye ligand 2'[2'-(1-hydroxy-4-methyl phenyl)azo]imidazole (HMePAI) was prepared by reaction between diazonium chloride salt solution of 2'-amino-4-methyl phenol with imidazole in alkaline ethanolic solution. Nine metal complexes with Cr(III), Mn(II), Fe(III), Co(III), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) ions were prepared and characterized by analytical and spectral techniques like elemental analysis (CHN), metal contents, molar conductance, magnetic moments, 1H NMR, Mass spectra, infrared, electronic spectral, XRD spectra, SEM and thermal studies (TGA & DSC). The results indicated that the ligand (HMePAI) behaves as a tridentate in case of 1:2 [metal:ligand] complexes. Investigation of the stereochemistry of metal complexes have octahedral geometry. Biological activity of ligand (HMePAI) and its metal complexes against two types of bacteria, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) by agar plate different technique. The biological activity was also conducted by cells viability and cytotoxicity assay on ligand and Ni(II) complex by using the lines of cancerous liver cells of the type HEPG2 and compared with line of the ordinary cells.

Keywords

Azo imidazole Metal complexes Synthesis and Characterization Biological activity
Al-Adilee, K. J., & Atyha, S. A. (2017). Synthesis, Spectral, Thermal and Biological Studies of Some Metal Complexes Derived from Heterocyclic Mono Azo Dye Ligand 2’[(2’-Hydroxy-4-methyl phenyl)azo]imidazole. Asian Journal of Chemistry, 30(2), 280–292. https://doi.org/10.14233/ajchem.2018.20889
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