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Art of Synthesis of Desired Polymorphs: A Review

https://doi.org/10.14233/ajchem.2018.20934
Runjhun Tandon
Department of Chemistry, Lovely Professional University, Jalandhar-Delhi G.T. Road, Phagwara-144 411, India
Nitin Tandon
Department of Chemistry, Lovely Professional University, Jalandhar-Delhi G.T. Road, Phagwara-144 411, India
Neelima Gupta
Department of Chemistry, Rajasthan University, J.L.N. Marg, Jaipur-302 004, India
Raakhi Gupta
Department of Chemistry, IIS University, Jaipur-302 020, India

Corresponding Author(s) : Nitin Tandon

tandonnitin12004@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 1 (2018): Vol 30 Issue 1

Abstract

Polymorphism plays an important role in drug solubility and availability. The study of the polymorphism of active pharmaceutical ingredients has become crucial for the synthesis of active pharmaceutical ingredients. This review provides observations, synthetic methods and characterization techniques for polymorphs using the latest analytical techniques. The desired polymorph can be obtained by choosing the proper nucleation mechanism.

Keywords

Polymorphism Amorphous Crystalline Nucleation Crystallization
Tandon, R., Tandon, N., Gupta, N., & Gupta, R. (2017). Art of Synthesis of Desired Polymorphs: A Review. Asian Journal of Chemistry, 30(1), 5–14. https://doi.org/10.14233/ajchem.2018.20934
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