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Vol. 28 No. 11 (2016): Vol 28 Issue 11

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Synthesis and Characterization of Neodymium(III) Ternary Complex Using Lansoprazole and Uracil as Ligands

https://doi.org/10.14233/ajchem.2016.19935
Sarika Verma
Council of Scientific and Industrial Research-Advanced Materials and Processes Research Institute, Hoshangabad Road, Bhopal-462 064, India
Sarita Shrivastva
Institute for Excellence in Higher Education, Ravi Shankar Nagar, Bhopal-462 016, India
S.S. Amritphale
Council of Scientific and Industrial Research-Advanced Materials and Processes Research Institute, Hoshangabad Road, Bhopal-462 064, India
Satyabrata Das
Council of Scientific and Industrial Research-Advanced Materials and Processes Research Institute, Hoshangabad Road, Bhopal-462 064, India

Corresponding Author(s) : Sarika Verma

drsarikaverma@hotmail.com

Asian Journal of Chemistry, Vol. 28 No. 11 (2016): Vol 28 Issue 11

Abstract

Ternary complex of neodymium has been synthesized by reacting neodymium(III) nitrate hexahydrate with two different (dual) biochemical ligands. One of the ligand used is an antiulcer drug, lansoprazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-yl]methyl]sulfinyl]-1H-benzimidazole, other is uracil which is a RNA bases. The complex was synthesized in ethanolic medium and refluxed in reaction medium in 1:1:1, M:L:L ratio. The percentage yield of synthesized neodymium complex was 93 %. The complex was purple coloured solid and of the type (Llanso.Nd.LUra.4H2O)X·nH2O, where X is NO42-. The synthesized complex was characterized by various complementary techniques namely elemental analysis, Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy (1H NMR), ultra violet-visible spectroscopy, mass spectroscopy, X-ray diffraction, scanning electron microscopy. An IR spectrum indicates that all the ligands behave as bidentate ligand. Molar conductance studies indicate electrolytic behaviour of the complex. Free energy changes were also calculated of synthesized complex. The complex has been screened for their antibacterial activity towards Streptococus faecalis bacteria. The results revealed that the metal chelates showed more resistance as compared with parent drug.

Keywords

Neodymium Spectroscopy Lansoprazole Uracil Antibacterial activity
Verma, S., Shrivastva, S., Amritphale, S., & Das, S. (2016). Synthesis and Characterization of Neodymium(III) Ternary Complex Using Lansoprazole and Uracil as Ligands. Asian Journal of Chemistry, 28(11), 2379–2384. https://doi.org/10.14233/ajchem.2016.19935
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