Synthesis and Biological Evaluation of Novel 2,4-Thiazolidinedione Derivatives as Antibacterial Agent

Abstract

A novel series of 5-[1-substituted-3-(substituted phenyl)allylidine]thiazolidine-2,4-dione was synthesized. The target compounds 3(a-l) were synthesized by azotropic removal of water by condensation of 2,4-thiazolidinedione with substituted benzylideneacetones/substituted cinnamaldehyde in presence of piperidine. The spectral characteristics (FT-IR, ¹H NMR spectroscopy) and physical properties (melting point) of the synthesized compounds were identified. The compounds synthesized were evaluated for their antibacterial activity by using cup plate method and minimum inhibitory concentration by two fold serial dilution method. The screening results of the synthesized compounds indicated that the compound (3a), (3b), (3c), (3e), (3f), (3g), (3h), (3i), (3j), (3l) exhibited significant antibacterial activity against gram positive and gram negative bacteria.