Study on Diclazuril Polyethylene Glycol 6000 Solid Dispersions with Improved Solubility

Abstract

Present study investigated diclazuril/polyethyleneglycol 6000 solid dispersions (diclazuril/ PEG6000 SDs) with improved solubility. The solid dispersions were prepared by solvent-melting method with PEG 6000 as carrier. It was validated by differential thermal analysis and cumulative dissolution rate. The solubility of diclazuril, mixture and solid dispersions were measured. The UV spectrophotometer method was developed for determination diclazuril. It was found that the spectra of cumulative dissolution rate, differential thermal analysis of the solid dispersions were different from the diclazuril and physical mixture. Solubility of diclazuril was enhanced for the formation of solid dispersions. The calibration curve was linear with an correlation coefficient r = 0.9997 in range of 5-20 μg/mL. The method was simple and practical in preparation and determination the diclazuril solid dispersions.