Studies on Antiinflammatory, Antipyretic and Analgesic Activities of Aporusa oblonga Mull Arg

Abstract

Aporusa oblonga Mull. Arg. (Euphorbiaceae) is a well known for its medicinal and traditional use in Mizoram (north eastern part of India). It is commonly used by local folklores for the treatment of various ailments which include stomach ache, ulcer, diarrhoea and dysentery. However, to be clinically useful, more scientific data are needed. Therefore, in the present study, we investigated the effect of Aporusa oblonga on acute and chronic inflammation and by thermally induced pain stimulus for its antiinflammatory and analgesic activities in animal models. To assess the antiinflammatory and analgesic properties varied concentrations of methanolic extract of Aporusa oblonga (100, 200, 400 mg/kg, orally) were tested in carrageenan-induced rat paw oedema, cotton pellet granuloma, brewer's yeast induced pyrexia, acetic induced writhing, formalin test, tail flick test and hot plate reaction time in experimental rats. The paw volume in experimental rats were reduced significantly (p < 0.05) as compared to that of control and hot plate test showed significant (jumping) effect in rats. These results clearly indicate that the stem bark of Aporusa oblonga used traditionally by people in Mizoram could be a potential source for using as antiinflammatory and analgesic agent.