Synthesis and Biocompatible Properties of a New Glycerylsilane

Abstract

This paper presents an approach to the preparation of a new glycerylsilane with glycerol and tetraethyl orthosilicate, using Amberlyst 15 (dry), an acidic ion-exchange resin, as catalyst. Trypsin was selected as a model enzyme to study the biocompatible properties of the resultant glycerylsilane by comparing the properties of trypsin in solution, trypsin entrapped in tetraethyl orthosilicate and the resultant glycerylsilane derived sol-gel matrix. The enzyme entrapped into the glycerylsilane derived sol-gel glass exhibits improved properties, which is not found in free enzyme and conventional sol-gel glass and the result indicates the glycerylsilane has good biocompatible properties.