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Vol. 24 No. 11 (2012): Vol 24 Issue 11

Lipase Catalyzed Synthesis of Anticancer Compound: 3b-(3-Methylphthalyl)-lup-20(29)-ene-28-oic

F.B.H. Ahmad
Department of Chemistry, Faculty of Science, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
C.N.L. Peter
Department of Chemistry, Faculty of Science, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
M.B. Abdul Rahman
Department of Chemistry, Faculty of Science, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia ; Structural Biology Research Centre, Malaysia Genome Institute, UKM-MTDC Smart Technology Centre, UKM Bangi 43600, Selangor, Malaysia
M. Basri
Department of Chemistry, Faculty of Science, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia

Corresponding Author(s) : F.B.H. Ahmad

faujan@fsas.upm.edu.my

Asian Journal of Chemistry, Vol. 24 No. 11 (2012): Vol 24 Issue 11

Abstract

Lipase catalyzed synthesis reaction of betulinic acid with 3-methylphthalic anhydride in presence of Novozyme 435 as biocatalyst gave 3b-(3-methylphthalyl)-lup-20(29)-ene-28-oic acid, which is a new candidate for anticancer agent. The reaction was carried out in chloroform at 37 ºC for 24 h. 3b-(3-methylphthalyl)-lup-20(29)-ene-28-oic acid showed a higher cytotoxicity as compare to parent compound.

Keywords

Betulinic acid Betulinic ester Enzyme Cytotoxicity
(1)
Ahmad, F.; Peter, C.; Abdul Rahman, M.; Basri, M. Lipase Catalyzed Synthesis of Anticancer Compound: 3b-(3-Methylphthalyl)-Lup-20(29)-Ene-28-Oic. ajc 2012, 24, 4875-4877.
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