Lipase Catalyzed Synthesis of Anticancer Compound: 3b-(3-Methylphthalyl)-lup-20(29)-ene-28-oic
Corresponding Author(s) : F.B.H. Ahmad
faujan@fsas.upm.edu.my
Asian Journal of Chemistry,
Vol. 24 No. 11 (2012): Vol 24 Issue 11
Abstract
Lipase catalyzed synthesis reaction of betulinic acid with 3-methylphthalic anhydride in presence of Novozyme 435 as biocatalyst gave 3b-(3-methylphthalyl)-lup-20(29)-ene-28-oic acid, which is a new candidate for anticancer agent. The reaction was carried out in chloroform at 37 ºC for 24 h. 3b-(3-methylphthalyl)-lup-20(29)-ene-28-oic acid showed a higher cytotoxicity as compare to parent compound.
Keywords
Betulinic acid
Betulinic ester
Enzyme
Cytotoxicity
Ahmad, F., Peter, C., Abdul Rahman, M., & Basri, M. (2012). Lipase Catalyzed Synthesis of Anticancer Compound: 3b-(3-Methylphthalyl)-lup-20(29)-ene-28-oic. Asian Journal of Chemistry, 24(11), 4875–4877. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/9785
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