Preparation and Characterization, Theoretical Treatment and Antibacterial of Mixed Ligand Complexes of Indol and N-Methyl Imidazol with Some Metal Ions

Abstract

An ethanolic solution of indol (In) was added to an aqueous solution of metal salt. This is followed by adding N-methyl imidazol (Im) and aqueous solution to give complexes with the general formula [M(In)(Im)Cl₂] where M= Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) ion. The metal complexes have been prepared and characterized by different analytical and spectral methods: FT-IR and UV-VIS. Spectroscopy and atomic absorption technique. The molar conductance studies of the complexes in DMSO at 10^-3 concentration indicate their non-electrolytic nature for all prepared complexes. Room temperature magnetic susceptibility measurements tetrahedral structure. A theoretical treatment of the formation of complexes in the gas phase was studied, this was done using the HYPERCHEM-6 program for the molecular mechanics and semi-empirical calculations. The biological evaluation of the free ligand in comparison to their metal-complexes have been determined against bacterial strains e.g., Escherichia coli and Staphylococcus. Finally, it was found that compounds show different activity of inhibition on growth of the bacteria.