Synthesis, Crystal Structure and Biological Activity of 1-Cyano-N-(2,4-dichlorophenyl)cyclopropanecarboxamide

Abstract

A cyclopropane derivative, 1-cyano-N-(2,4-dichlorophenyl)cyclopropanecarboxamide (C₁₁H₈N₂OCl₂) was synthesized and its structure was studied by X-ray diffraction, FTIR, ¹H NMR, MS and elemental analysis. The crystals are monoclinic, space group C2 with a = 14.387(9), b = 6.926(4), c = 12.237(7) Å, a = 90.00, b = 100.386(10), g = 90.00°, V = 1199.4(12) ų, Z = 4, F(000) = 520, D_c = 1.413 g/cm³, μ = 0.520 cm^-1, the final R = 0.0603 and wR = 0.1653. A total of 2976 reflections were collected, of which 1134 were independent (R_int = 0.0381). The preliminary biological test showed that the synthesized compound is bioactive against the KARI of Escherichia coli.