Liquid Selective Electrodes for Warfarin Sodium Based on Poly(vinyl chloride) Matrix Membrane

Yehya K. Al-Bayati; Khaleda H. Al-Saidi; Maysam A. Hussain

doi:10.14233/ajchem.2016.19852

Issue

Vol. 28 No. 9 (2016): Vol 28 Issue 9

Issue Published : June 1, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

Liquid Selective Electrodes for Warfarin Sodium Based on Poly(vinyl chloride) Matrix Membrane

https://doi.org/10.14233/ajchem.2016.19852

Yehya K. Al-Bayati

Chemistry Department, College of Science, Baghdad University, Al-Jaderai, Baghdad, Iraq

Khaleda H. Al-Saidi

Chemistry Department, Al-Nahrain University, Al-Jaderia, Baghdad, Iraq

Maysam A. Hussain

Chemistry Department, Al-Nahrain University, Al-Jaderia, Baghdad, Iraq

Corresponding Author(s) : Yehya K. Al-Bayati

yahyaalbayti@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 9 (2016): Vol 28 Issue 9
Article Published : June 2, 2016

Abstract

An accurate, sensitive, selective and reproducible method for quantification of warfarin sodium in pharmaceutical preparation has been developed. This method is based on construction of selective liquid membrane electrodes using phosphotungstic acid as an active material and oleic acid, tri-n-butylphosphate, nitrobenzene, acetophenone and di-octyl phthalate as plasticizers and PVC as matrix. The results showed that the linear concentration is between 1 × 10^–1 and 1 × 10^–5 M, correlation coefficient of (0.9984 and 0.99949), slope of (20.04 -29.6) mV/decade, detection limit of (6 × 10^–6 to 4 × 10^–5) M and the life time were (10-40) days. This study also included the measurements of selectivity coefficients of these electrodes in the presence of common cations and some amino acid they found to be less than one. The electrodes were successfully applied for determination of warfarin sodium in pure form and in pharmaceutical tablets.

Keywords

Warfarin sodium Ion selective electrode Phosphotungstic acid Different plasticizers

Al-Bayati, Y. K., Al-Saidi, K. H., & Hussain, M. A. (2016). Liquid Selective Electrodes for Warfarin Sodium Based on Poly(vinyl chloride) Matrix Membrane. Asian Journal of Chemistry, 28(9), 1962–1966. https://doi.org/10.14233/ajchem.2016.19852

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References

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References

Martindale, The Complete Drug Reference, Pharmaceutical Press Publication Division of Royal Pharmaceutical Society, Great Britain, edn 33, p. 998 (2002).

K.D. Tripathi, Essentials of Medical Pharmacology, edn 3, p. 555 (1985).

S.G. Kini, S. Choudhary and M. Mubeen, J. Computat. Methods Mol. Des., 2, 51 (2012).

M.P. Teotia, D.K. Rastogi and W.U. Malik, Anal. Chim. Acta, 7, 339 (1973).

D. Singh and H.B. Singh, Indian J. Chem., 14, 781 (1976).

U. Yasar, E. Eliasson, M. Dahl, I. Johansson, M. Ingelman-Sundberg and F. Sjoqvist, Biochem. Biophys. Res. Commun., 254, 628 (1999); doi:10.1006/bbrc.1998.9992.

A.T.M. Serajuddin, Adv. Drug Deliv. Rev., 59, 603 (2007); doi:10.1016/j.addr.2007.05.010.

D. Gao and M.B. Maurin, AAPS PharmSci, 3, 18 (2001); doi:10.1208/ps030103.

A. Vacobi, J.A. Udall and G. Levy, Clin. Pharmacol. Ther., 19, 552 (1976); doi:10.1002/cpt1976195part1552.

F.V. Lucas, A. Duncan, R. Jay, R. Coleman, P. Craft, B. Chan, L. Winfrey, D.R. Mungall and J. Hirsh, Am. J. Clin. Pathol., 88, 442 (1987); doi:10.1093/ajcp/88.4.442.

Y.A. Chua, W.Z. Abdullah and S.H. Gan, Turk. J. Med. Sci., 42, 930 (2012).

I. Locatelli, V. Kmetec, A. Mrhar and I. Grabnar, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 818, 191 (2005); doi:10.1016/j.jchromb.2004.12.024.

C. Banfield and M. Rowlandx, J. Pharm. Sci., 73, 1392 (1984); doi:10.1002/jps.2600731017.

H. Takahashi, T. Kashima, S. Kimura, N. Muramoto, H. Nakahata, S. Kubo, Y. Shimoyama, M. Kajiwara and H. Echizen, J. Chromatogr. B Biomed. Sci. Appl., 701, 71 (1997); doi:10.1016/S0378-4347(97)00346-0.

A. Duffield, P.H. Duffield, D.J. Birkett, M. Kennedy and D.N. Wade, Biomed. Mass Spectrom., 6, 208 (1979); doi:10.1002/bms.1200060508.

M.R. Nateghi, M.H. Mosslemin, A. Hakimi and S. Kavoosi, Asian J. Chem., 22, 3516 (2010).

M.M. Ghoneim and A. Tawfik, Anal. Chim. Acta, 511, 63 (2004); doi:10.1016/j.aca.2004.01.037.

T.D. Smirnova, N.V. Nevryueva, S.N. Shtykov, V.I. Kochubei and D.A. Zhemerichkin, J. Anal. Chem., 64, 1114 (2009); doi:10.1134/S1061934809110045.

Z. Chang and H.T. Yan, J. Lumin., 132, 811 (2012); doi:10.1016/j.jlumin.2011.11.013.

Q. Zhou, W.P. Yau and E. Chan, Electrophoresis, 24, 2617 (2003); doi:10.1002/elps.200305441.

P. Gareil, J.P. Gramond and F. Guyon, J. Chromatogr. B, 615, 317 (1993); doi:10.1016/0378-4347(93)80347-7.

F. Faridbod, M.R. Ganjali, R. Dinarvand and P. Norouzi, Afr. J. Biotechnol., 6, 2960 (2007).

Y. Umezawa, K. Umezawa and H. Sato, Pure Appl. Chem., 67, 507 (1995); doi:10.1351/pac199567030507.

Ch.C. Rundl, A Beginners Guide to Ion Selective Electrodes Measurement, Nico2000 Ltd., London, UK (2004).

Issue

Vol. 28 No. 9 (2016): Vol 28 Issue 9

Liquid Selective Electrodes for Warfarin Sodium Based on Poly(vinyl chloride) Matrix Membrane

Corresponding Author(s) : Yehya K. Al-Bayati

Abstract

Keywords

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