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Synthesis, Characterization and Microbial Activity of N-Substituted Pyrazolines
Corresponding Author(s) : Jyoti Gaba
Asian Journal of Chemistry,
Vol. 28 No. 9 (2016): Vol 28 Issue 9
Abstract
Acetic acid and propanoic acid were treated with thionyl chloride to give respective acid chlorides, which were then reacted with synthesized pyrazolines using triethylamine as catalyst in dry dichloromethane to give N-acetylated pyrazolines (1b-7b) and N-propanoylated pyrazolines (1c-7c). Synthesized N-substituted pyrazolines were characterized by IR, 1H NMR and 13C NMR spectral studies. Prepared compounds were screened for their microbial activity against Bacillus sp., Pseudomonas sp., Acinetobactor sp. and Klebsiella sp. N-acetylated (7b) and N-propanoylated (7c) pyrazolines having substitution of methoxy group at meta position and hydroxy group at para position of benzene ring were found effective against Bacillus sp., Acinetobactor sp. and Pseudomonas sp. but not against Klebsiella sp. All pyrazolines and N-substituted pyrazolines exhibited less activity than standard ampicillin at all the tested concentrations.
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- B. Insuasty, A. Tigreros, F. Orozco, J. Quiroga, R. Abonía, M. Nogueras, A. Sanchez and J. Cobo, Bioorg. Med. Chem., 18, 4965 (2010); doi:10.1016/j.bmc.2010.06.013.
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References
B. Insuasty, A. Tigreros, F. Orozco, J. Quiroga, R. Abonía, M. Nogueras, A. Sanchez and J. Cobo, Bioorg. Med. Chem., 18, 4965 (2010); doi:10.1016/j.bmc.2010.06.013.
A.E. Rashad, M.I. Hegab, R.E. Abdel-Megeid, J.A. Micky and F.M.E. Abdel-Megeid, Bioorg. Med. Chem., 16, 7102 (2008); doi:10.1016/j.bmc.2008.06.054.
R.V. Ragavan, V. Vijayakumar and N.S. Kumari, Eur. J. Med. Chem., 45, 1173 (2010); doi:10.1016/j.ejmech.2009.12.042.
D. Kim, Y. Lee, Y.W. Lee, P.M. Dewang, Y.Y. Sheen, Y.W. Kim, H. Park, J. Yoo, H.S. Lee and Y. Kim, Bioorg. Med. Chem., 18, 4459 (2010); doi:10.1016/j.bmc.2010.04.071.
J. Gaba, S. Sharma, G. Arora, S. Joshi and A. Goyal, J. Indian Chem. Soc., 92, 1587 (2015).
S. Kaur, S. Sharma, J. Kaur and P. Sharma, Indian J. Chem., 52B, 1513 (2013).
V.M. Barot and S.N. Panchal, Asian J. Biochem. Pharm. Res., 4, 212 (2012).