Determination of Residual Solvents in Marbofloxacin by Capillary Gas Chromatography

Abstract

The residual solvents in marbofloxacin were determined in this study. Under the optimized conditions, ethyl acetate, dichloro methane, methyl benzene and N,N-dimethyl formamide were detected by capillary gas chromatograph with flame ionization detector. The results showed that the four organic solvents could get a good separation and the internal standard acetonitrile had no effect on the determination. In the test concentration range, the linear relationship was good (r > 99 %) and the RSD values were less than 2 %. The established method is simple, efficient and can be used for the determination of residual solvents in marbofloxacin.