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Vol. 28 No. 9 (2016): Vol 28 Issue 9

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Formulation and Evaluation of Clarithromycin Bioadhesive Tablets

https://doi.org/10.14233/ajchem.2016.19842
Atul Gunjal
Jodhpur National University, Jodhpur-342 003, India
Gali Vidyasagar
Virayatan Institute of Pharmacy, Bhuj-Mandvi Highway, Jakhania-370 460, India
Santosh Ghule
IPS Academy, College of Pharmacy, Indore-452 012, India

Corresponding Author(s) : Atul Gunjal

atulgunjalkmk@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 9 (2016): Vol 28 Issue 9

Abstract

Gastroretentive clarithromycin floating tablets for the eradication of Helicobacter pylori were prepared using the matrix forming polymer hydroxypropyl methylcellulose (HPMC K15M), in different ratios by wet granulation method. Buoyancy of formulated tablets was achieved by an addition of an effervescent mixture consisting of sodium bicarbonate to some formulations. The prepared floating tablets were characterized for weight variation, thickness, friability, hardness, drug content, in vitro buoyancy, water uptake and in vitro release. The prepared floating tablets revealed satisfactory physicochemical characteristics. Incorporation of gas-generating agent improved the floating parameters. HPMC K15M floating tablet formulation (CF1) offered the best controlled drug release (> 8 h) along with floating lag time < 1 s and total floating time > 24 h. The value of n in case of CF1 (n = 0.37) revealed a Fickian diffusion mechanism of formulated floating tablets.

Keywords

Gastroretentive Floating tablets Helicobacter pylori Fickian diffusion
Gunjal, A., Vidyasagar, G., & Ghule, S. (2016). Formulation and Evaluation of Clarithromycin Bioadhesive Tablets. Asian Journal of Chemistry, 28(9), 1944–1948. https://doi.org/10.14233/ajchem.2016.19842
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