Synthesis and Pharmacological Activity of 2-((4,5-Disubstituted pyridin-2-yl)methylthio)-6-methoxypyrimidin-4-ol
Corresponding Author(s) : S. Kotaiah
salikanti.kotaiahjntu@gmail.com
Asian Journal of Chemistry,
Vol. 24 No. 9 (2012): Vol 24 Issue 9
Abstract
2-(Chloromethyl)-4,5-disubstitutedpyridine hydrochloride 1 (1a, 1b) on condensation with 2-mercapto-6-methylpyrimidin-4-ol(2)under conventional and green conditions gave 2-[(4,5- disubstitutedpyridin-2-yl)methylthio]-6-methoxypyrimidin-4-ol (3) (3a, 3b). The structures of compound 3 have been established by their spectral and analytical data.
Keywords
triethylamine
K2CO3
PEG-600
2-(Chloromethyl)-4,5-dimethoxypyridine hydrochloride
2-mercapto-6- methylpyrimidin-4-ol
Kotaiah, S., Ramadevi, B., Naidu, A., & Dubey, P. (2012). Synthesis and Pharmacological Activity of 2-((4,5-Disubstituted pyridin-2-yl)methylthio)-6-methoxypyrimidin-4-ol. Asian Journal of Chemistry, 24(9), 3884–3886. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/9490
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