Fading Spectrophotometric Determination of Pioglitazone Hydrochloride with Eosine B
Wei-Xing Ma
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu Province, P.R. China ; Jiangsu-Marine Resources Development Research Institute, Lianyungang 222005, Jiangsu Province, P.R. China ; Key Lab of Applied Chemistry, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu Province, P.R.China
Na Li
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu Province, P.R. China
Ou Sha
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu Province, P.R. China
Ying-Hong Liu
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu Province, P.R. China
Corresponding Author(s) : Wei-Xing Ma
weixingma650528@163.com; weixingma650528@126.com
Asian Journal of Chemistry,
Vol. 24 No. 8 (2012): Vol 24 Issue 8
A fading spectrophotometric method for the determination of pioglitazone hydrochloride was carried out based on the reaction between pioglitazone hydrochloride and eosine B to form ion-association complex with the fading absorption peak at 518 nm, where the absorbance DA was correlated with its concentration. Linear relationship with good correlation coefficient (0.9996) was found between the absorbance DA and the concentration of pioglitazone hydrochloride in a concentration range of 3-27 μg mL-1. The proposed method was successfully applied to the determination of the investigated drug in tablets or capsules in agreement with the results of ultraviolet spectrophotometry.
Ma, W.-X., Li, N., Sha, O., & Liu, Y.-H. (2012). Fading Spectrophotometric Determination of Pioglitazone Hydrochloride with Eosine B. Asian Journal of Chemistry, 24(8), 3487–3489. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/9417
