A Green and Simple Synthesis of N-Alkyl-2-acetylbenzimidazoles

Abstract

A green and simple synthesis of N-alkyl-2-substituted benzimidazoles has been developed. In this method, 2-acetyl benzimidazole compound (1) was alkylated with reagents such as dimethyl sulfate/diethyl sulfate/benzyl chloride under green conditions i.e., by physical grinding in presence of a mild base like K₂CO₃ or by using green solvents like PEG-600, ethanol etc. or by using micro-wave irradiation technique to obtain N-alkyl-2-acetylbenzimidazoles compound (2)