Novel Quinazolin-3(H)-4-one Derivatives by Microwave Synthesis

Abstract

The substituted quinazolinones are reported to possesses anticonvulsant activity as they are cyclic amides and exhibit potent AMPAR non-competitive antagonism. The intermediate compound, 2-phenyl-4H-3,1-benzoxazin-4-one was synthesized from anthranilic acid and benzoyl chloride and converted to 3-amino-2-phenylquinazolin-4-(3H)-one by treating with hydrazine hydrate. The quinazolin-3(H)-4-one derivatives were prepared by condensation of amino group with selected aldehydes or ketones. The test compounds were characterized by interpreting UV, IR, Mass and ¹H NMR spectra.