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Vol. 28 No. 8 (2016): Vol 28 Issue 8

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Synthesis, Characterization and Biological Studies of Cu(II), Ni(II), Co(II) and VO(IV) Complexes of Tridentate ONO Donor with N'-[(E)-3-Bromo-5-chloro-2-hydroxybenzylidene]nicotinohydrazide

https://doi.org/10.14233/ajchem.2016.19780
M. Prabhu
Department of Chemistry, GKM College of Engineering & Technology, Chennai-600 063, India
K. Parthiban
Department of Chemistry, SIVET College, Chennai-600 073, India
G. Chakkaravarthi
Department of Physics, CPCL Polytechnic College, Chennai-600 068, India
E. Prabakaran
Department of Chemistry, GKM College of Engineering & Technology, Chennai-600 063, India
G. Rajagopal
Department of Chemistry, Chikkanna Government Arts College, Tiruppur-641 602, India

Corresponding Author(s) : G. Rajagopal

rajagopal18@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 8 (2016): Vol 28 Issue 8

Abstract

New Cu(II), Ni(II), Co(II) and VO(IV) complexes of the Schiff base, N’-[(E)-3-bromo-5-chloro-2-hydroxybenzylidene]nicotinohydrazide have been synthesized and characterized by NMR, MS, IR, electronic, magnetic measurements, EPR, redox properties and XRD. The ligand coordinates through one of the phenolic–O, azomethine–N and amide–O atoms to metal ions as shown by IR measurements. Electronic and magnetic measurements have been corroborative of a square-planar geometry for Cu(II) complex, octahedral geometry for Ni(II), Co(II) complexes and square pyramidal geometry for vanadium complex. The observed anisotropic ‘g’ values also confirm the presence of Cu(II) in a square planar environment and VO(IV) complex in a square pyramidal coordination geometry around the metal centre. The redox properties of the metal complexes have been investigated by cyclic voltammetry. Preliminary antibacterial screening shows the promising results against bacterial strains. The compounds have shown promising cytotoxic activity when screened using the in vitro method on human breast adenocarcinoma (MCF-7) cells.

Keywords

Tridentate hydrazone ligand Schiff base Transition metal complexes Antibacterial activity Cytotoxicity activity
Prabhu, M., Parthiban, K., Chakkaravarthi, G., Prabakaran, E., & Rajagopal, G. (2016). Synthesis, Characterization and Biological Studies of Cu(II), Ni(II), Co(II) and VO(IV) Complexes of Tridentate ONO Donor with N’-[(E)-3-Bromo-5-chloro-2-hydroxybenzylidene]nicotinohydrazide. Asian Journal of Chemistry, 28(8), 1661–1666. https://doi.org/10.14233/ajchem.2016.19780
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