Synthesis and Antimicrobial Evaluation of Some New Pyrazole, Fused Pyrazolo[1,5-a]- pyrimidine and Pyrazolo[1,5-d]pyrimido[4,5-d][1,2,3]triazine Derivatives

Abstract

A variety of 3-arylazo-5-amino and 7-amino pyrazolo[1,5-a] pyrimidines were obtained via reacting 1 with cinnamonitriles and methoxymethylene malononitrile. Diazotized 1 coupled with active methylene reagents to yield pyrazolo[5,1-c][1,2,4]triazines. The products were screened for their antifungal and antibacterial activity properties and showed promising results. The mechanism of the studied reactions is discussed. The structures of the compounds prepared were elucidated on the basis of their elemental analyses, spectral data and alternate synthesis.