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Vol. 28 No. 8 (2016): Vol 28 Issue 8

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Synthesis, Spectral Characterization and Antibacterial Study of Schiff Base Metal Complexes Derived from 4-Bromo-N-[(E)-(5-chloro-2-hydroxyphenyl)methylidene]benzenesulfonamide

https://doi.org/10.14233/ajchem.2016.19771
Farmanullah Khan
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Fatima Syed
Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan
Arshiya Iqbal
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Zia-Ul-Haq Khan
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Hamid Ullah
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan
Shafiullah Khan
Institute of Chemical Sciences, Gomal University, D.I. Khan, Pakistan

Corresponding Author(s) : Shafiullah Khan

s.khan@gu.edu.pk

Asian Journal of Chemistry, Vol. 28 No. 8 (2016): Vol 28 Issue 8

Abstract

A new sulfonamide Schiff based 4-bromo-N-[(E)-(5-chloro-2-hydroxyphenyl)methylidene]benzenesulfonamide prepared by refluxing 5-chloro-2-hydroxybenzaldehyde and 4-bromobenzenesulfonamide. The Schiff base was used as a complexing agent for the Cu, Co, Ni and Zn complexes. All the metal complexes were characterized by micro-analytical data, 1H NMR, FT-IR and electronic spectra. The spectral data suggest coordination of Schiff base ligand with metal through nitrogen and oxygen atom and proves the bidentate nature of ligand. The biological screening effect of Schiff base and their metal complexes were studied against Gram-positive and Gram-negative bacteria by disc-diffusion technique. The biological activity shows that complex exhibit higher antibacterial activity than that of Schiff base against tested bacteria.

Keywords

Schiff base Metal complexes Spectroscopic study Biological activity
Khan, F., Syed, F., Iqbal, A., Khan, Z.-U.-H., Ullah, H., & Khan, S. (2016). Synthesis, Spectral Characterization and Antibacterial Study of Schiff Base Metal Complexes Derived from 4-Bromo-N-[(E)-(5-chloro-2-hydroxyphenyl)methylidene]benzenesulfonamide. Asian Journal of Chemistry, 28(8), 1658–1660. https://doi.org/10.14233/ajchem.2016.19771
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