Synthesis, Antibacterial and Antifungal Activities of Some Novel Derivatives of Thiazolo[2,3-b]dihydropyrimidine Possessing 4-Pyrazolyl Moiety

Abstract

A series of new 2-arylidene-5-(5-chloro-3-methyl-1-N-phenyl-pyrazol-4-yl)-6-carbethoxy-7- methyl-5H-thiazolo[2,3-b]pyrimidin-3(1H)-ones have been synthesized by a three component (MCR) reaction involving 4-(5-chloro-3-methyl-1-N-phenyl- pyrazol-4-yl)-5-carbethoxy-6- methyl-3,4-dihydropyrimidin-2(1H)-thione, monochloroacetyl chloride and aryl aldehydes. The newly synthesized compounds were well characterized by elemental analysis, IR, ¹H NMR and mass spectral studies. The newly synthesized compounds were screened for their antibacterial and antifungal activities and have exhibited moderate to excellent growth inhibition of bacteria and fungi.