Biokinetics Study of 1000-mg Cefaclor Tablet in Stray Dogs

Abstract

Pharmacokinetic of cefaclor (1000 mg tablet) were assessed after single oral administration in stray dogs. Serial blood samples were collected in heparinized tubes at pre-scheduled time intervals and analyzed by microbiological assay against gram negative and gram positive bacterial strains by disc diffusion method. The concentration data obtained from bioassay were subjected for biokinetics. Peaked concentration of cefaclor was reached after 2 h in dog blood plasma. Average plasma concentration remained above minimum inhibitory concentration (MIC) value from 0.5 to 10.0 h. The values of maximum plasma concentration (C_max) were found to be 18, 19.80, 21.10 and 20.17 mg/L and time of peak (T_max) was found to 2.80, 1.35, 1.99 and 1.95 h against Escherichia coli, Staphalococuss aureus, Pasturella multocida and Basillus subtilis, respectively. Absorption half life (t_1/2) was ranged from 1.30-1.96 h against four strains. The difference in biokinetics parameter was found non-significant (p < 0.05) in case of gender. It is concluded that the oral administration of 1000 mg cefaclor as tablet twice a day may maintain significant concentration in dogs and effective for the treatment of infections in dogs due to above mentioned microbes.