Synthesis, Characterization and in vitro Cytotoxic Assay on Human Promyelocytic Leukemia Cells (HL60) of Organotin(IV) Complexes Derived of 4-(methylamino) benzoic Acid and 4-(Dimethylamino)benzoic Acid

Abstract

Organotin(IV) carboxylate complexes derived from 4-(methylamino)benzoic acid, 4-(NHCH₃)C₆H₄COOH and 4-(dimethylamino)benzoic acid, 4-[N(CH₃)₂]C₆H₄COOH have been successfully synthesized. Two dibutyltin(IV) complexes with the general formulae [4- (R')C₆H₄COO]₂Bu₂Sn [R' = NHCH₃ 1; R' = N(CH₃)₂ 3] and another two triphenyltin(IV) complexes with the general formulae 4- (R')C₆H₄COO(C₆H₅)₃Sn [R' = NHCH₃ 2; R' = N(CH₃)₂ 4] were successfully synthesized. The acids and complexes 1-4 obtained were characterized quantitatively and qualitatively. Results of the infrared and NMR spectroscopy on the acids and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. From the cytotoxic assay study, complex 2 revealed a significant result compared to complexes 1, 3 and 4.