Synthesis, Characterization and in vitro Cytotoxic Assay on Human Promyelocytic Leukemia Cells (HL60) of Organotin(IV) Complexes Derived of 4-(methylamino) benzoic Acid and 4-(Dimethylamino)benzoic Acid
Yip-Foo Win
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan University, Bandar Barat, 31900 Kampar, Perak, Malaysia ; School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia
Siang-Guan Teoh
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia
Yang-Farina Abdul-Aziz
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
Ibrahim Baba
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
Emad Yousif
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
Corresponding Author(s) : Yip-Foo Win
williamyfw@yahoo.com
Asian Journal of Chemistry,
Vol. 24 No. 5 (2012): Vol 24 Issue 5
Organotin(IV) carboxylate complexes derived from 4-(methylamino)benzoic acid, 4-(NHCH3)C6H4COOH and 4-(dimethylamino)benzoic acid, 4-[N(CH3)2]C6H4COOH have been successfully synthesized. Two dibutyltin(IV) complexes with the general formulae [4- (R')C6H4COO]2Bu2Sn [R' = NHCH3 1; R' = N(CH3)2 3] and another two triphenyltin(IV) complexes with the general formulae 4- (R')C6H4COO(C6H5)3Sn [R' = NHCH3 2; R' = N(CH3)2 4] were successfully synthesized. The acids and complexes 1-4 obtained were characterized quantitatively and qualitatively. Results of the infrared and NMR spectroscopy on the acids and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. From the cytotoxic assay study, complex 2 revealed a significant result compared to complexes 1, 3 and 4.
Win, Y.-F., Teoh, S.-G., Abdul-Aziz, Y.-F., Baba, I., & Yousif, E. (2012). Synthesis, Characterization and in vitro Cytotoxic Assay on Human Promyelocytic Leukemia Cells (HL60) of Organotin(IV) Complexes Derived of 4-(methylamino) benzoic Acid and 4-(Dimethylamino)benzoic Acid. Asian Journal of Chemistry, 24(5), 2117–2120. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/9024
