Synthesis of Some Quinolone Derivatives with Possible Local Anaesthetics Activities

Abstract

Various new 7-[N-substituted acetyl amino]-2-methyl-4-quinolone were systheized by condensing 2-methyl-7-amino-4-quinolone with chloroacetyl chloride to get 2-methyl-7-chloroacetyl amino-4-quinolone, which on further reaction with various secondary amines to afford the required derivatives. The compounds were tested for their local anesthetic activity.