Synthesis and Antifungal Activity of 2-Thiazoleacrylonitrile Derivatives

Abstract

A coupling reaction of 2-[4-(2,6-difluorophenyl)thiazol-2-yl]acetonitrile and desired acid chlorides were occurred in the presence of triethylamine leading to 3-hydroxy-2-thiazolylacrylonitrile derivatives, then further reacted with acid chlorides to obtain twelve novel 3-esterified-2-thiazolylacrylonitrile derivatives (yields 70.8-87.3 %). The structures of the 2-thiazoleacrylonitrile derivatives were characterized by ¹H NMR, mass spectra and elemental analysis. Antifungal activities against Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Colletotrichum gossypii were also evaluated by the mycelium growth rate method. The results indicated that these compounds possess certain antifungal activity.