Design and Synthesis of Two Brucine Derivatives and Evaluation of Its Antibacterial Activity Against Escherichia coli and Salmonella typhi
Lauro Figueroa-Valverde
Laboratorio de Ciencias Biológicas y Farmacoquímica, Facultad de Ciencias QuímicoBiológicas, Universidad Autónoma de Campeche, Av. Agustín Melgar, Col Buenavista C.P., 24039 Campeche Cam., México
Francisco Diaz-Cedillo
Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, C.P. 11340, México, D.F.
Maria Lopez-Ramos
Laboratorio de Ciencias Biológicas y Farmacoquímica, Facultad de Ciencias QuímicoBiológicas, Universidad Autónoma de Campeche, Av. Agustín Melgar, Col Buenavista C.P., 24039 Campeche Cam., México
Elodia Garcia-Cervera
Laboratorio de Ciencias Biológicas y Farmacoquímica, Facultad de Ciencias QuímicoBiológicas, Universidad Autónoma de Campeche, Av. Agustín Melgar, Col Buenavista C.P., 24039 Campeche Cam., México
Eduardo Pool-Gomez
Laboratorio de Ciencias Biológicas y Farmacoquímica, Facultad de Ciencias QuímicoBiológicas, Universidad Autónoma de Campeche, Av. Agustín Melgar, Col Buenavista C.P., 24039 Campeche Cam., México
Corresponding Author(s) : Lauro Figueroa-Valverde
lauro_1999@yahoo.com
Asian Journal of Chemistry,
Vol. 24 No. 5 (2012): Vol 24 Issue 5
In this study two brucine derivatives were synthesized. The first step was achieved by the reaction of brucine with ethylenediamine using boric acid as catalyst to form an imine group (Schiff base) involved in the compound 3. The second step involves the coupling of ethylenediamine to brucine by the method reported by Mannich, using formaldehyde to form the compound 4. The antibacterial activity of both brucine derivatives was evaluated in vitro on Escherichia coli and Salmonella typhi using the dilution method and the minimum inhibitory concentration. The results showed that bacterial growth of Escherichia coli was inhibited by the compounds 3 and 4 in a dose-dependent manner. Nevertheless, the bacterial growth of Salmonella typhi only was blocked by the compound 3. These data suggest that functional groups involved in the structure of 3 are specific for its antibacterial activity.
Figueroa-Valverde, L., Diaz-Cedillo, F., Lopez-Ramos, M., Garcia-Cervera, E., & Pool-Gomez, E. (2012). Design and Synthesis of Two Brucine Derivatives and Evaluation of Its Antibacterial Activity Against Escherichia coli and Salmonella typhi. Asian Journal of Chemistry, 24(5), 2173–2176. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/8973