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Vol. 28 No. 8 (2016): Vol 28 Issue 8

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Zirconia/Poly(oxalic acid) Modified Carbon Paste Electrode for Electrochemical Investigation of Uric Acid in Presence of Dopamine and Ascorbic Acid

https://doi.org/10.14233/ajchem.2016.19877
V. Prabhakara Rao
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
Y. Veera Manohara Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
M. Lavanya
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
M. Venu
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
G. Madhavi
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India

Corresponding Author(s) : G. Madhavi

gmchem01@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 8 (2016): Vol 28 Issue 8

Abstract

The electrochemistry of uric acid in the presence of dopamine and ascorbic acid was studied by cyclic voltammetry at a carbon paste electrode modified with zirconia and oxalic acid to get zirconia/poly(oxalic acid) modified carbon paste electrode (ZrO2/POA/CPE). The modified electrode could resolve well the anodic peaks of uric acid, dopamine and ascorbic acid and also showed far better sensitivity for uric acid (two folds) compared to bare carbon paste electrode. Scan rate studies indicated that the electrode process was both diffusion and adsorption controlled. The limit of detection (LOD) and limit of quantification (LOQ) of the modified electrode for uric acid were found to be 5.07 × 10-7 M and 1.69 × 10-6 M respectively. The recovery percentage of uric acid in human urine and human blood serum were found to be 92 and 97 respectively with ZrO2/POA/CPE in the real sample analysis. The modified electrode was found to be very selective, sensitive, inexpensive, stable and provide a good possibility for applying the technique in the routine analysis of biomolecules in medicine and analytical chemistry.

Keywords

Dopamine Uric acid Ascorbic acid Zirconia Oxalic acid Cyclic voltammetry
Rao, V. P., Manohara Reddy, Y. V., Lavanya, M., Venu, M., & Madhavi, G. (2016). Zirconia/Poly(oxalic acid) Modified Carbon Paste Electrode for Electrochemical Investigation of Uric Acid in Presence of Dopamine and Ascorbic Acid. Asian Journal of Chemistry, 28(8), 1828–1834. https://doi.org/10.14233/ajchem.2016.19877
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