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Vol. 28 No. 8 (2016): Vol 28 Issue 8

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Anticoagulant Activity and Molecular Docking of 7,9-bis(4-Chlorophenyl)-6-methyl-1,4-dioxa-8-azaspiro[4.5]decane through Target Protein Thrombin

https://doi.org/10.14233/ajchem.2016.19821
N. Manivannan
Department of Chemistry, V.R.S. College of Engineering and Technology, Arasur, Villupuram-607 107, India
S. Sugunakala
Department of Bio-informatics, A.V.C. College (Autonomous), Mannampandal, Mayiladuthurai-609 305, India
B. Elanchezhian
Department of Chemistry, A.V.C. College (Autonomous), Mannampandal, Mayiladuthurai-609 305, India
G. Selvanathan
Department of Chemistry, A.V.C. College (Autonomous), Mannampandal, Mayiladuthurai-609 305, India

Corresponding Author(s) : N. Manivannan

nmrmani@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 8 (2016): Vol 28 Issue 8

Abstract

The present study reported the synthesis and anticoagulant activity of spiro compounds, the potential compound was subjected to study their binding mode and interaction using bioinformatics tools. Among the five compounds tested, 7,9-bis(4-chlorophenyl)-6-methyl-1,4,8-triaza spiro[4.5]decane has prolonged activated partial thromboplastin time and prothrombin time as 22.7s and 18.5s at 25 μg mL-1, respectively. Hence, the mandatory way study was carried out for this compound by using bioinformatics method. The interaction results shows that this compound binds in the active site of the target protein thrombin which is similar to that of existing inhibitor and it may also considered as an anticoagulant drug in future.

Keywords

Anticoagulant Prothrombin Spiro and Thrombin inhibitor
Manivannan, N., Sugunakala, S., Elanchezhian, B., & Selvanathan, G. (2016). Anticoagulant Activity and Molecular Docking of 7,9-bis(4-Chlorophenyl)-6-methyl-1,4-dioxa-8-azaspiro[4.5]decane through Target Protein Thrombin. Asian Journal of Chemistry, 28(8), 1777–1782. https://doi.org/10.14233/ajchem.2016.19821
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