Synthesis of a Progesterone-Carbachol Derivative: Relationship with Some Parameters Involved in its Geometry and Electronic Structure

Abstract

In this study, a progesterone-carbachol (3) derivative was synthetized and its relationship with some physicochemical parameters involved in its geometry and electronic structure wasevaluated. The results showed an increase in the HOMO/LUMO, logP and p values of compound 3 with respect to progesterone. All this datasuggest that changes in the chemical structure of progesterone to form progesterone-carbacholexert variations in HOMO/LUMO, logP and p values.