in vitro Evaluation of Zeolite Nanoparticles as Carrier for Delivery of 5-Fluorouracil

Hamdallah A. Hodali; Dua'a M. Marzouqa

doi:10.14233/ajchem.2016.19724

Issue

Vol. 28 No. 7 (2016): Vol 28 Issue 7

Issue Published : March 31, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

in vitro Evaluation of Zeolite Nanoparticles as Carrier for Delivery of 5-Fluorouracil

https://doi.org/10.14233/ajchem.2016.19724

Hamdallah A. Hodali

Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan

Dua'a M. Marzouqa

Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan

Corresponding Author(s) : Hamdallah A. Hodali

h-hodali@ju.edu.jo; hodali19@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 7 (2016): Vol 28 Issue 7
Article Published : March 31, 2016

Abstract

The aim of the work is to evaluate the use of zeolite ZSM-5 nanoparticles for loading and release of 5-fluorouracil. Nanoparticles of zeolite ZSM-5 with different SiO₂/Al₂O₃ ratios have been prepared in both the sodium and acid form. All nanoparticle samples of ZSM-5 were loaded with the model anticancer drug 5-fluorouracil. The loaded and unloaded nanoparticle samples were characterized by XRD, SEM, TGA and FTIR. Loading of ZSM-5 samples was performed in an aqueous saturated solution of 5-fluorouracil. A loading greater than 50 % was achieved for the acid-activated nanopatricles of ZSM-5 with a SiO₂/Al₂O₃ ratio of 30 (in the starting gel). The release experiments were conducted in simulated body fluid at a pH of 7.4 and 37 °C. In general, the acid-activated nanoparticles of ZSM-5 show higher percent loading, lower percent release and smaller first order rate constant than the corresponding non-activated samples.

Keywords

5-Fluorouracil ZSM-5 Nanoparticles Acid-activated Anticancer drugs

Hodali, H. A., & Marzouqa, D. M. (2016). in vitro Evaluation of Zeolite Nanoparticles as Carrier for Delivery of 5-Fluorouracil. Asian Journal of Chemistry, 28(7), 1479–1485. https://doi.org/10.14233/ajchem.2016.19724

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References

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D.B. Longley, D.P. Harkin and P.G. Johnston, Nat. Rev. Cancer, 3, 330 (2003); doi:10.1038/nrc1074.

S. Yan, J. Zhu, Z. Wang, J. Yin, Y. Zheng and X. Chen, Eur. J. Pharm. Biopharm., 78, 336 (2011); doi:10.1016/j.ejpb.2010.12.031.

T.A. Rich, R.C. Shepard and S.T. Mosley, J. Clin. Oncol., 22, 2214 (2004); doi:10.1200/JCO.2004.08.009.

R.B. Diasio and B.E. Harris, Clin. Pharmacokinet., 16, 215 (1989); doi:10.2165/00003088-198916040-00002.

R.C. Mundargi, V. Rangaswamy and T.M. Aminabhavi, Desig. Monomers Polym., 13, 325 (2010); doi:10.1163/138577210X509561.

J.L. Arias, Molecules, 13, 2340 (2008); doi:10.3390/molecules13102340; J.L. Arias, M. Lopez-Viota, A.V. Delgado and M.A. Ruiz, Colloids Surf. B, 77, 111 (2010); doi:10.1016/j.colsurfb.2010.01.030.

M. Danilczuk, K. Dlugopolska, T. Ruman and D. Pogocki, Mini Rev. Med. Chem., 8, 1407 (2008); doi:10.2174/138955708786369537.

D.G. Fatouros, D. Douroumis, V. Nikolakis, S. Ntais, A.M. Moschovi, V. Trivedi, B. Khima, M. Roldo, H. Nazar and P.A. Cox, J. Mater. Chem., 21, 7789 (2011); doi:10.1039/c1jm10204d.

I.S. Braschi, S. Blasioli, L. Gigli, C.E. Gessa, A. Alberti and A. Martucci, J. Hazard. Mater., 178, 218 (2010); doi:10.1016/j.jhazmat.2010.01.066.

N. Vilaca, R. Amorim, O. Martinho, R.M. Reis, F. Baltazar, A.M. Fonseca and I.C. Neves, J. Mater. Sci., 46, 7511 (2011); doi:10.1007/s10853-011-5722-2.

M. Arruebo, R. Fernandez-Pacheco, S. Irusta, J. Arbiol, M.R. Ibarra and J. Santamaría, J. Nanotechnol., 17, 4057 (2006); doi:10.1088/0957-4484/17/16/011.

A. Datt, D. Fields and S.C. Larsen, J. Phys. Chem. C, 116, 21382 (2012); doi:10.1021/jp3067266.

A. Datt, E.A. Burns, N.A. Dhuna and S.C. Larsen, Micropor. Mesopor. Mater., 167, 182 (2013); doi:10.1016/j.micromeso.2012.09.011.

M. Spanakis, N. Bouropoulos, D. Theodoropoulos, L. Sygellou, S. Ewart, A.M. Moschovi, A. Siokou, I. Niopas, K. Kachrimanis, V. Nikolakis, P.A. Cox, I.S. Vizirianakis and D.G. Fatouros, Nanomedicine, 10, 197 (2014); doi:10.1016/j.nano.2013.06.016.

R. Al-Thawabeia and H.A. Hodali, J. Chem., Article ID 403597 (2015); doi:10.1155/2015/403597.

Y.C. Barenholz, J. Control. Rel., 160, 117 (2012); doi:10.1016/j.jconrel.2012.03.020.

H. Mochizuki, T. Yokoi, H. Imai, R. Watanabe, S. Namba, J.N. Kondo and T. Tatsumi, Micropor. Mesopor. Mater., 145, 165 (2011); doi:10.1016/j.micromeso.2011.05.011.

A. Saito and H.C. Foley, Micropor. Mater., 3, 543 (1995); doi:10.1016/0927-6513(94)00064-3.

A. Oyane, H. Kim, T. Furuya, T. Kokubo, T. Miyazaki and T. Nakamura, J. Biomed. Mater. Res., 65A, 188 (2003); doi:10.1002/jbm.a.10482.

D.M. Marzouqa, M.B. Zughul, M.O. Taha and H.A. Hodali, J. Porous Mater., 19, 825 (2012); doi:10.1007/s10934-011-9537-y.

T. Heikkila, J. Salonen, J. Tuura, N. Kumar, T. Salmi, D.Y. Murzin, M.S. Hamdy, G. Mul, L. Laitinen, A.M. Kaukonen, J. Hirvonen and V.P. Lehto, Drug Deliv., 14, 337 (2007); doi:10.1080/10717540601098823.

P. Costa and J.M. Sousa Lobo, Eur. J. Pharm. Sci., 13, 123 (2001); doi:10.1016/S0928-0987(01)00095-1.

Issue

Vol. 28 No. 7 (2016): Vol 28 Issue 7

in vitro Evaluation of Zeolite Nanoparticles as Carrier for Delivery of 5-Fluorouracil

Corresponding Author(s) : Hamdallah A. Hodali

Abstract

Keywords

Full Article

Download Citation

References

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