Synthesis and Biological Activities of 2-[3-(4-Morpholino)propylthio]-5-(difluromethoxy)benzimidazole Derivatives
Weiming Cheng
Department of Traditional Chinese Medicine, Zhejiang Institute for Food and Drug Control, No. 86 Jichang Road, Jianggan Dist. 310004, Hangzhou Zhejiang Province, P.R. China
Rihong Tan
Department of Chemistry, Science College of Shenyang University, No. 21 Wanghuanan Road, Dadong Dist. 110044, Shenyang Liaoning Province, P.R. China
Yongchi Zeng
Hangzhou Innovation TCM Standarization Research Institute Co. Ltd., No. 677 Binkang Road, Binjiang Dist. 310053, Hangzhou Zhejiang Province, P.R. China
Wei Huang
College of Pharmaceutical Science, Zhejiang Chinese Medcical University, No. 548 Bingwen Road, Binjiang Dist. 310053, Hangzhou Zhejiang Province, P.R. China
Wenting Zhang
Department of Traditional Chinese Medicine, Zhejiang Institute for Food and Drug Control, No. 86 Jichang Road, Jianggan Dist. 310004, Hangzhou Zhejiang Province, P.R. China
Corresponding Author(s) : Wenting Zhang
leozhwt@163.com
Asian Journal of Chemistry,
Vol. 24 No. 5 (2012): Vol 24 Issue 5
Benzimidazole derivatives exhibit some important pharmacological actions in animals and human beings. The synthesis and pharmacological effects of two novel synthesized compounds, 2-[3-(4-morpholino)propylthio]-5-(difluromethoxy)benzimidazole (BM1) and 2-[3-(4-morpholino)ethylthio]-5-(difluromethoxy)benzimidazole (BM2), were described in this work. The tests showed that BM1 had better antiinflammatory effect than aspirin and better analgesia activity than indomethacin, while these two compounds had lower side effect of gastric ulcer than aspirin. Therefore, BM1 was an ideal antiinflammatory compound for further development.
Keywords
Benzimidazole derivativesSynthesisAntiinflammatory and Analgesia activitiesSide effect of gastric ulcer
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Cheng, W., Tan, R., Zeng, Y., Huang, W., & Zhang, W. (2012). Synthesis and Biological Activities of 2-[3-(4-Morpholino)propylthio]-5-(difluromethoxy)benzimidazole Derivatives. Asian Journal of Chemistry, 24(5), 1996–1998. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/8938