Effect of Sertraline in Indomethacin-Induced Gastric Mucosal Damage

Abstract

The antiulcerative effect of sertraline was investigated using an indomethacin-induced ulcer model in rats. After the macroscopic analyses, malondialdehyde and glutathione amounts and superoxide dismutase, glutathione-S-transferase and glutathione peroxidase enzyme activities were determined in stomach tissues. It is presumed that the sertraline has positive effect in the treatment of gastric mucosal damages and this effect may be related to the decrease of oxidative stress and activation of antioxidant mechanisms by sertraline. For clinical use of sertraline by this effect, more prospective randomized studies should be done.