A Critical Review on Analytical and Biological Applications of Thio- and Phenylthiosemicarbazones: A Review

Abstract

In present study, we summarized the analytical applications of thio- and phenylthiosemicarbazones in metal ions separation and determination from various samples by using spectrophotometer. We reviewed the analytical applications of thio and phenylthiosemicarbazones from 1991 to 2011. This two decades survey is very useful to the analytical chemists working on separation and determination of metal ions and biological activities of their complexes. In this article first we summarized the basic introduction and structural information of thio- and phenylthiosemicarbazones and then we reviewed their analytical applications in the separation and determination of metal ions from real samples, synthetic samples and alloy samples. Finally we discussed their biological activities. The literature survey reveals that the thio and phenyl thiosemicarbazones are promising chelating agents for the separation and determination of transitional metal ions. In addition to this the complexes formed by thio and phenylthiosemciarbazones with transitional metal ions are having biological activities.