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Phytochemical and Biological Investigations of Ravenia spectabilis
Corresponding Author(s) : Fatema Tabassum
Asian Journal of Chemistry,
Vol. 31 No. 1 (2019): Vol 31 Issue 1
Abstract
The methanolic extract of the leaves of Ravenia spectabilis was investigated for isolation of secondary metabolites and evaluation of bioactivities. Two alkaloids ravenoline (1) and arborinine (2) were obtained by using vacuum liquid chromatography, gel permeation chromatography and PTLC. The compounds were identified by NMR spectroscopy and by comparing the NMR data with those published in the literature. The pure compounds and the petroleum ether, carbon tetrachloride, chloroform and aqueous soluble fractions of the crude methanolic extract of the plant were evaluated for thrombolytic, antioxidant and antimicrobial properties. In the study for thrombolytic property, the pure compounds and different fractions showed thrombolytic activity ranging from 30.43 to 48.85 % as compared to standard streptokinase (74.34 %). All the fractions and the pure compounds showed mild to moderate antibacterial activity. Carbon tetrachloride fraction showed moderate antioxidant activity (97.53 μg/mL) as compared to BHT (27.50 μg/mL), whereas other fractions showed mild antioxidant activity.
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- C.M. Hasan, N. Ahmed, R. Haque, M.M. Haque, S. Begum, M.H. Sohrab and M. Ahsan, Pharmacogn. Mag., 9, 76 (2013); https://doi.org/10.4103/0973-1296.108147.
- V.H. Heywood, Flowering Plants of The World, Oxford University Press, New York, 202 (1993).
- M.M. Haque, S. Begum, M.H. Sohrab, M. Ahsan, C.M. Hasan, N. Ahmed and R. Haque, Pharmacogn. Mag., 9, 76 (2013); https://doi.org/10.4103/0973-1296.108147.
- G.A. Usher, Dictionary of Plants used by Man. Constable: London (1974).
- J.L. Hartwell, Lloydia, 34, 153 (1971).
- G.H. Svoboda, G.A. Poore, P.J. Simpson and G.B. Boder, J. Pharm. Sci., 55, 758 (1966); https://doi.org/10.1002/jps.2600550803.
- P.G. Waterman, eds.: P.G. Waterman and M.F. Grundon, Chemistry and Chemical Taxonomy of the Rutales, Academic Press: London, p. 337 (1983).
- K.C. Das and P.K. Bose, Trans. Bose Res. Inst. (Calcutta), 26, 129 (1963).
- B.D. Paul and P.K. Bose, Indian J. Chem., 7, 678 (1969).
- M. Kupinic, M. Medic-Šaric, M. Movrin and D. Maysinger, J. Pharm. Sci., 68, 459 (1979); https://doi.org/10.1002/jps.2600680417.
- P. Bhattacharyya and B.K. Chowdhury, Phytochemistry, 23, 1825 (1984); https://doi.org/10.1016/S0031-9422(00)83512-8.
- M.A. Khan and P.G. Waterman, Fitoterapia, 61, 282 (1990).
- A. Alam, M. Asaduzzaman and N. Nasrin, Int. J. Pharmacog. Pharm. Res., 3, 80 (2011)
- M.H. Sohrab, R. Chowdhury, K.M. Rahman, C.M. Hasan and M.A. Rashid, Fitoterapia, 75, 510 (2004); https://doi.org/10.1016/j.fitote.2004.03.008.
- S. Morris Kupchan, Pure Appl. Chem., 21, 227 (1970); https://doi.org/10.1351/pac197021020227.
- B.C. VanWagenen, R. Larsen, J.H. Cardellina, D. Randazzo, Z.C. Lidert and C. Swithenbank, J. Org. Chem., 58, 335 (1993); https://doi.org/10.1021/jo00054a013.
- S. Prasad, R.S. Kashyap, J.Y. Deopujari, H.J. Purohit, G.M. Taori and H.F. Daginawala, BMC Complement. Altern. Med., 7, 36 (2007); https://doi.org/10.1186/1472-6882-7-36.
- W. Brand-Williams, M.E. Cuvelier and C. Berset, Lebensm.-Wiss. Technol., 28, 25 (1995); https://doi.org/10.1016/S0023-6438(95)80008-5.
- A.W. Bauer, W.M. Kirby, J.C. Sherris and M. Turck, Am. J. Clin. Pathol., 45(4_ts), 493 (1966); https://doi.org/10.1093/ajcp/45.4_ts.493.
References
C.M. Hasan, N. Ahmed, R. Haque, M.M. Haque, S. Begum, M.H. Sohrab and M. Ahsan, Pharmacogn. Mag., 9, 76 (2013); https://doi.org/10.4103/0973-1296.108147.
V.H. Heywood, Flowering Plants of The World, Oxford University Press, New York, 202 (1993).
M.M. Haque, S. Begum, M.H. Sohrab, M. Ahsan, C.M. Hasan, N. Ahmed and R. Haque, Pharmacogn. Mag., 9, 76 (2013); https://doi.org/10.4103/0973-1296.108147.
G.A. Usher, Dictionary of Plants used by Man. Constable: London (1974).
J.L. Hartwell, Lloydia, 34, 153 (1971).
G.H. Svoboda, G.A. Poore, P.J. Simpson and G.B. Boder, J. Pharm. Sci., 55, 758 (1966); https://doi.org/10.1002/jps.2600550803.
P.G. Waterman, eds.: P.G. Waterman and M.F. Grundon, Chemistry and Chemical Taxonomy of the Rutales, Academic Press: London, p. 337 (1983).
K.C. Das and P.K. Bose, Trans. Bose Res. Inst. (Calcutta), 26, 129 (1963).
B.D. Paul and P.K. Bose, Indian J. Chem., 7, 678 (1969).
M. Kupinic, M. Medic-Šaric, M. Movrin and D. Maysinger, J. Pharm. Sci., 68, 459 (1979); https://doi.org/10.1002/jps.2600680417.
P. Bhattacharyya and B.K. Chowdhury, Phytochemistry, 23, 1825 (1984); https://doi.org/10.1016/S0031-9422(00)83512-8.
M.A. Khan and P.G. Waterman, Fitoterapia, 61, 282 (1990).
A. Alam, M. Asaduzzaman and N. Nasrin, Int. J. Pharmacog. Pharm. Res., 3, 80 (2011)
M.H. Sohrab, R. Chowdhury, K.M. Rahman, C.M. Hasan and M.A. Rashid, Fitoterapia, 75, 510 (2004); https://doi.org/10.1016/j.fitote.2004.03.008.
S. Morris Kupchan, Pure Appl. Chem., 21, 227 (1970); https://doi.org/10.1351/pac197021020227.
B.C. VanWagenen, R. Larsen, J.H. Cardellina, D. Randazzo, Z.C. Lidert and C. Swithenbank, J. Org. Chem., 58, 335 (1993); https://doi.org/10.1021/jo00054a013.
S. Prasad, R.S. Kashyap, J.Y. Deopujari, H.J. Purohit, G.M. Taori and H.F. Daginawala, BMC Complement. Altern. Med., 7, 36 (2007); https://doi.org/10.1186/1472-6882-7-36.
W. Brand-Williams, M.E. Cuvelier and C. Berset, Lebensm.-Wiss. Technol., 28, 25 (1995); https://doi.org/10.1016/S0023-6438(95)80008-5.
A.W. Bauer, W.M. Kirby, J.C. Sherris and M. Turck, Am. J. Clin. Pathol., 45(4_ts), 493 (1966); https://doi.org/10.1093/ajcp/45.4_ts.493.