Efficient Synthesis of DOPA Analogues in Pepticinnamins E via Asymmetric Catalytic Hydrogenation of Dehydroamino Esters

Abstract

One practical synthetic procedure with five steps was developed to prepare a series of N-protected-2-(diethoxyphosphoryl)glycinates with good yields, which was treated with aldehydes under mild condition to give different dehydroamino esters with high yields and excellent Z/E selectivity. The subsequently homogeneous enantioselective hydrogenation of the dehydroamino esters affords a series of new DOPA analogues.