Investigation of Ecotoxic Effect of 2,4-Dichlorophenoxyacetic Acid Dimethylamine on Liver and Pancreas

Abstract

In this study, ecotoxic effects of 2,4-dichlorophenoxyacetic acid dimethylamine salt herbicide were investigated on the liver and pancreas of rats. Azaserine-rat model developed by Longnecker and Curphey was used in this research. As a result of this study, hydropic degenerations in parenchyma which were on the point of being more distinct in localized hepatocytes especially in the vena centralis periphery of the liver, dilatation in sinusoids and kupffer cell proliferation were observed. It was found that 200 mg/kg/day dose of 2,4-dichlorophenoxyacetic acid dimethylamine salt caused the formation of neoplastic variations in the pancreas and liver of rats. It was also indicated that the development of neoplastic variations which were experimentally formed by using azaserine was increased (diameter of focus, volume of focus). These results indicate the possibility of these herbicides to be cancer initiator during long exposures.